![]() These studies provide valuable information on the carcinogenic potential of these complex organic mixtures. The mutagenesis section is primarily concerned with the results of microbial mutagenesis studies with synfuel materials. Of particular importance in carcinogenesis has been the demonstration that the carcinogenic potencies of complex organic synfuel mixtures may be much lower (or, occasionally, higher) than the sum of the potencies of the more ยป individual components. This year we include a report on our 22nd Hanford Life Sciences Symposium, which dealt with this problem of extrapolating the results of animal studies to man. These data, along with metabolism and modeling studies, provide a basis for predicting human risks in the absence of relevant human exposure. The section on carcinogenesis presents results from laboratory animal dose-effect relationship studies from both nuclear and synfuels materials. Since some projects have multiple objectives, a section may contain data concerning other endpoints as well. The next three sections, which contain reports of health effects research in biological systems, are grouped according to the major endpoint being studied: carcinogenesis, mutagenesis, and systems damage. ![]() ![]() The first section is devoted to an evaluation of possible health effects among nuclear workers. This report summarizes progress on Office of Health and Environmental Research (OHER) biomedical and health effects research conducted at PNL in FY 1983 to develop the information required for a comprehensive understanding of the interaction of energy-related pollutants with living organisms. ![]()
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